Keyur P. Biology...Science Rasmussens Encephalitis The Human Immune Sy

Keyur P. Biology...Science Rasmussen's Encephalitis The human immune system is an amazing system that is constantly on the alert protecting us from sicknesses. Thousands of white blood cells travel in our circulatory system destroying all foreign substances that could cause harm to our body or to any of the millions of processes going on inside. Now imagine a condition where this awesome system turns against the most complex organ in the human body, the brain. Deadly as it is, this condition is known as Rasmussen's encephalitis. The meaningful research on Rasmussen's encephalitis was begun (unintentionally) by Scott Rogers and Lorise Gahring, two neurologists, who were at the time measuring the distribution of glutamate receptors in the brain. Later on when more provocative information was found they enlisted the help of James McNamara and Ian Andrews, epilepsy experts at Duke University Medical Center. The details on Rasmussen's encephalitis were very bleak at the time when the men began their research. All that was known is that Rasmussen's encephalitis was a degenerative disease of the brain that caused seizures, hemiparesis, and dementia normally in the first ten years of life. The seizures that were caused by Rasmussen's encephalitis were unstoppable by normal anti-seizure drugs used conventionally. What the worst part of the disease was that the pathogenesis for it were not known and even worse was how it developed. The first clue was delivered when Rogers and Gahring were trying to register the distribution of the glutamate receptors using antibodies, that tag on to the receptor itself. The proteins that make up the glutamate receptors(GluR) are only found inside the blood brain barrier(BBB). Glutamate and a few related amino acids are the dominant form of excitatory neurotransmitter in the central nervous system of mammals. If one of these GluRs happens to wander into the actual bloodstream, that is outside the BBB, it would be considered an outsider and destroyed immediately. So if these GluRs were put into the normal blood stream then the immune system would produce antibodies which could then be used in the searching for the glutamate receptors. In order to test this theory the researchers injected the GluRs into the blood stream of a normal healthy rabbit hoping to produce good results. At this point the experiment took a dramatic turn, after receiving a few doses of the protein two of the three rabbits began to twitch, as though they were suffering the pain of an epileptic seizure. Now the help of McNamara and Andrews was enlisted. When McNamara and Andrews examined the brain tissue of the rabbits, they saw what seemed to be a familiar inflammatory pattern, clumps of immune cells all around blood vessels. This description exactly matched the description of persons suffering from Rasmussen's encephalitis, moreover something as this would never be found in a healthy brain. A healthy br ain has its blood capillaries enclosed in the BBB membrane, so such a case as the one mentioned above would not be possible. As protective as the BBB is, it can be breached by something like a head injury. What was happening was that the antibodies which were out to get the GluR proteins were somehow finding a way into the brain and directing an attack towards all GluR receptor proteins in the brain itself. After some more examinations Rogers and McNamara decided that these attacks were the cause of the seizures that are often experienced by sufferers of Ramussen's encephalitis. Then if the case is of antibodies in the bloodstream, than sufferers of Ramussen's encephalitis should have them in their bloodstream and healthy normal peoples shouldn't. When this was actually tested the results were positive that Rasmussen sufferers did have these antibodies in their bloodstreams and healthy people did not. These were not only the right kind of antibodies but, the very antibodies that caused the seizures in people and rabbits. Thus when these antibodies were removed by plasma exchange(PEX) it caused a temporary relief from the seizures but soon the body starts making more antibodies of the type and the seizures start once again. After all the examinations two questions remained, why does the body mount an immune response against one of its own brain proteins,

Comparision Between The Metamorphosis and Siddhartha essays

Comparision Between The Metamorphosis and Siddhartha essays The Idea of Change in The Metamorphosis and Siddhartha Although The Metamorphosis by Franz Kafka and Siddhartha by Hermann Hesse are very different in approach, they both have a very significant similar theme, which is change. This change can also be called a transformation or a metamorphosis of the Self. Each character goes through different stages of the change, with each stage bringing them closer to their salvation. Thus, everything that the characters experience along their journeys is of importance. The necessity for change is more apparent in Siddhartha than in The Metamorphosis. However, both Gregor and Siddhartha must experience change and learn from their experiences before they are able to find the salvation that they desire. In the novella The Metamorphosis, Gregors life changes drastically, but it turns out to be the salvation he needs by the end. He undergoes a physical change that causes him to endure emotional changes as well. At the very beginning, the reader finds out that Gregor is not fond of his job and merely does it to take care of his family, because his fathers business failed years ago. This indicates that Gregor is trapped by his job because he feels an obligation to provide for his family. The metamorphosis into an insect suggests that this change is the only way for him to escape and be free, because as an insect he is not able to take care of his family. However, it turns out that he cannot escape this burden, because after the metamorphosis his family is disgusted by him and keeps him locked into his room, causing him to still be trapped. This signifies how they really feel about him. They feel that he is as useless as an insect, which causes him to sink deeper into his bug-lik e state. Though the physical change that Gregor endures is very abrupt, it causes him to go through another slower change. This change is him realizing that his family can take care of themselves with...

5 Funny Figures of Speech

5 Funny Figures of Speech 5 Funny Figures of Speech 5 Funny Figures of Speech By Mark Nichol Wordplay is a fertile field for study in English. Although the following forms of humor should be used sparingly if at all, writers should be familiar with them and their possibilities. 1. Malapropism A malapropism, the substitution of a word with a similar-sounding but incongruous word, may be uttered accidentally or, for humorous effect, may be deliberate. The name derives from that of Mrs. Malaprop, a character in an eighteenth-century play who often uttered such misstatements; one of her comments, for example, is â€Å"she’s as headstrong as an allegory,† when she meant to say â€Å"alligator.† (The word ultimately derives from the French phrase mal propos, meaning â€Å"poorly placed.†) Numerous characters are assigned this amusing attribute; the Shakespearean character Dogberry’s name inspired an alternate label. 2. Spoonerism Spoonerisms are similar to malapropisms; the distinction is that a spoonerism is a case of metathesis, in which parts of two words are exchanged, rather than one word substituted for another. This figure of speech was named after a nineteenth-century Oxford academician who appears to have been credited with various misstatements he did not make; one of the many apocryphal examples is â€Å"a well-boiled icicle† (in lieu of â€Å"a well-oiled bicycle†). 3. Paraprosdokian The word for this type of wordplay, from Greek (meaning â€Å"against expectation†) but coined only a few decades ago, refers to a sentence with a humorously abrupt shift in intent, such as â€Å"I don’t belong to an organized political party I’m a Democrat,† from twentieth-century American humorist Will Rogers, or Winston’s Churchill’s summation of a colleague, â€Å"A modest man, who has much to be modest about.† 4. Tom Swifty This name for an adverb, used in an attribution for dialogue, that punningly applies to the words spoken (for example, â€Å"‘We just struck oil!’ Tom gushed†) was inspired by the writing style in a series of children’s novels featuring the character Tom Swift, written continuously since the early twentieth century. Although no such puns appear in these stories, such examples are suggestive of the overwrought adverbs that are a distinctive feature. (Originally, such a pun was called a Tom Swiftly.) 5. Wellerism A Wellerism, named after a Dickensian character, is a statement that includes a humorous contradiction or a quirky lapse in logic, such as â€Å"‘So I see,’ said the blind carpenter as he picked up his hammer and saw,† or a prosaic similar construction whose humor derives from a pun, as in â€Å"‘We’ll have to rehearse that,’ said the undertaker as the coffin fell out of the car† (which plays on the prefix re- in association with the noun hearse). Want to improve your English in five minutes a day? Get a subscription and start receiving our writing tips and exercises daily! Keep learning! Browse the Writing Basics category, check our popular posts, or choose a related post below:Using "a" and "an" Before WordsWhen to Form a Plural with an ApostropheAdverbs and Hyphens

Jim Sharpe Essay Example | Topics and Well Written Essays - 500 words

Jim Sharpe - Essay Example He has to find a business within the time period he has given himself. And finally time has to quickly adapt to this new role of his. He has to keep pace with the dynamics of the situation and keep increasing his learning curve. Sharpe is falling short of the capital required to make the deal. Thus he is going for a leveraged buyout. The upside of this way of transacting is the availability of liquidity and flipping. However, the second benefit is cut by the original owner. In case the business does not go well, Tim will be in whole lot of mess. The biggest culture change that he will experience is the unionized environment of his acquired company. Whereas previously in which ever company he has worked in there was zero tolerance for unionization. But in this company the previous owner has received quiet serious blows from the activities of the union. Tim is in a very tough situation and he needs the commitment of his employees to execute is turnaround strategy. If they do not comply with his orders than he would have much to lose as compared to his workers. If Press Alloy had been a subsidiary of large corporations than in it current situation, it would have been decide by the corporate CIO to put it out for divestitures or liquidate it. Tim might have received a comparatively lower price, because the people who are dissecting Press Alloy from the parent company are not looking to sell it at a profit. These people are happy with whatever they can muster. Their focus is to minimize the parent company’s losses arising due to Press Alloy’s unprofitable operations. The corporate guy responsible for the deal would have a minimum price to extract, whereas the original entrepreneur would be pricing the company according to the company’s earning potential, thereby shifting the paradigm of the entire negotiation

Micro Economics - Competition Essay Example | Topics and Well Written Essays - 1750 words

Micro Economics - Competition - Essay Example However, not all situations can the management plan on how to counter the competitors. In most cases, these situations arise due to unavoidable circumstances facing an organization. Whenever such situations arise, an organization’s management has to take drastic measures of solving the problem. How firms solve the problem of competition in the two scenarios forms the main discussion of this paper. Short-Run Decisions and Long Run Adjustments of Firms Facing Competition Introduction Competition occurs in perfect market structures where firms operate in a perfectly competitive market structure. In perfect competition, many small firms involved in the production of identical products with perfect access to resources and knowledge characterize the market structure. Firms operating in a perfectly competitive market structure face a horizontal and perfectly elastic and demand curve, a situation where marginal revenues are equal to average revenue. Characteristics of perfectly compet itive markets include perfect knowledge, freedom of entry and exit of firms, production of homogenous and identical units of output and many firms in operation. The structuring of a perfect market does not give an opportunity to a single firm to either influence the market price or market conditions, there are no governmental regulations and the assumption there is no existence of externalities. Body Faced with the problem of competition, organizations have to device ways and means of preserving their relevance in the market. Various factors affect the relevance of organizations in the industry they operate. Jain and Khanna (198) assert that quality and the popularity of an organization’s products among the customers determine the market share of that company in the market it operates. Competition indirectly acts as a quality controller. As companies increase their fight for a bigger cake in the entire market, they apply a number of measures. Firstly, companies increase their focus on the quality of products provided to the market while at the same time strives to offer the best prices in the market. Pricing is not an influential factor as high-end markets have indicated. Quality is the biggest factor influencing the market dynamics and purchasing behaviours of customers. Compromising quality of products adversely effects on the customers base of a company. Companies known to high quality products and services are associated with large market shares and subsequently report high revenues and profits. While laying down strategies for winning their competition, organizations apply a number of means and ways. Although every organization uses unique strategies in the market geared towards increasing its revenue sales, there are similar steps that organizations use to achieve these results. Either, an organization can opt for long term or short-term competition mitigation factors. While long-term plans needs a solid strategic plan and implementation schedule, short term decisions could be spontaneous and reactive. Reaction is a situation where a company facing high competition from other firms operating in the same industry takes drastic measures of countering that competition. Mainly, the management as measures of last result takes such measures. However, the management of an organization should be adequately prepared to counter any in eventualities whenever they occur in their operations. Whenever

Problem or Success of Implementing Tourism Essay Example for Free

Problem or Success of Implementing Tourism Essay The problem that has face by the owner of the Salak Denai Chalet is promotion to promote their service. They only promote their service via customer, facebook and blog only. But, facebook and blog not actively yet. Besides, the chalet that they build was doesnt have a plan and Majlis Daerah Yan was issued a summons to their business. Then, they had to spend a lot of money to hire the architect to draw plan to settle the problem with Majlis Daerah Yan. Besides, they have a lot of competition with other chalet around there that they was provided a better service and comfortable place to the customer. Sustainable and environmental affects towards project In every chalet at Salak Denai,its has their own pool. Only a river water of Batu Hampar that use to fill the pool. Besides, the owner of the chalet not use a chlorine to maintain the water cleaning. The owner of the chalet still preserve the natural condition of the forest. He always make sure that the area of surrounding was clean. The strength and success story of project The strength and success of project is Salak Denai has a five chalet with every chalet has their own pool. This success of project can was attracted the customer to rent the chalet. This chalet give more privacy to the customer when they want to picnic with their family.The owner of the chalet is more concern about the aurat of the muslim and he was highlighted this project in his business. So, the customer do not have to worried anymore about the aurat of their family because they get more privacy to swimming. This chalet become popular after he was organized his daughter wedding ceremony here. Now, every weekend and public holiday, this chalet was fully booked until March 2013. Only the weekday has no reservation from customer. Proposed new marketing plan As we know, this chalet was fully booked every weekend until March 2013. So, the owner must have a plan to build more chalet to accommodate the demand of the customer towards this chalet. In addition, the owner shall register the service with the minister of tourism so that all tourists can get information about the activities of Salak Denai chalet easily. Besides that ,owner must actively involve in the social network to promote the service The annual update about the info always like put pictures chalets along the information, update new-items added to the chalet and put the best service to compete with the newar chalets. How tourism can contribute to environmental conservation Salak Denai chalet use travel system which can preserve the natural condition such as using natural river water flowing into the pond in the chalet, built a house with the original wood from the trees and so on. Futhermore , owner of Salak Denai chalet not use substance can pollute the nature condition in that chalet area.

Charlemagne, or Charles the Great, King of the Franks :: Medieval Europe European History

Charlemagne, or Charles the Great, King of the Franks Charlemagne, or Charles the Great, King of the Franks (742-814), was a strong leader who unified Western Europe through military power and the blessing of the Church. His belief in the need for education among the Frankish people was to bring about religious, political, and educational reforms that would change the history of Europe. Charlemagne was born in 742 at Aachen, the son of Pepin(or Pippin) the Short and grandson of Charles Martel. His grandfather, Charles, had begun the process of unifying western Europe, in the belief that all people should be Christian. Charlemagne's father, Pepin, continued this process throughout his rule and passed his beliefs on to Charlemagne. All three, in addition to the political unification, believed that the church should be reformed and reorganized under the Pope, which helped their rise to power as the Carolingian Dynasty. (Holmes 74) Upon Pepin's death in 768, Charlemagne and his brother, Carloman, each inherited half of the Frankish kingdom. Pepin, in the Merovingian tradition of the time, split his kingdom between his two sons. Three years later Carloman died and Charlemagne took control of the entire kingdom. He inherited great wealth and a powerful army, built by his father and grandfather. Charlemagne used the army and his own skillful planning to more than double the size of the Frankish Kingdom. (Halsall 15) The world of Charlemagne was a heathen one, with many warring tribes or kingdoms. Many of these tribes were conquered by Charlemagne, among them the Aquitanians, the Lombards, the Saxons, the Bretons, the Bavarians, the Huns, and the Danes. The longest of these battles was against the Saxons, lasting thirty-three years. Charlemagne actually defeated them many times, but due to their faithlessness and their propensity to return to their pagan lifestyle, the Saxons lost many lives in the prolonged battles with the Franks. With each conquest the Frankish kingdom grew, and with growth came additional power and responsibility for Charlemagne. In each area of Europe that was taken over by Charlemagne, he removed the leaders if they would not convert to Christianity and appointed new ones, usually someone with high position in the Church. Those people who refused to convert or be baptized in the church were put to death. (Holmes 75) The Church played a vital role in the kingdom of Charlemagne. It gave a sense of stability to Charlemagne's rule, and he in turn provided stability in the Church. The people conquered by Charlemagne, after being converted to Christianity, were taught through the Bible a unified code of right and wrong. It was necessary for the Church to play a role in this education of the people,